In 2002, Mda5 was initially discovered as an interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties in human melanoma cells (19), and then in 2004, Mda5 was reported to play a major role in an intracellular signal transduction pathway, resulting in the activation of the IFN-β promoter, and V proteins of paramyxoviruses were shown to interact with Mda5 to block its activity (20). Here, IFNB1 is linked to melanoma.