For instance, overexpression of hsa_circ_0078710 increased cellular proliferation and migration, tumor growth and migration in human hepatocellular carcinoma (HCC) cell lines HepG2 and SMMC-7721 by sponging miR-31, increasing the expression levels of histone deacetylase 2 (HDAC2) and cyclin-dependent kinase 2 (CDK2) (Xie et al., 2018). This evidence concerns the gene CDK2 and hepatocellular carcinoma.