PCK1 and hepatocellular carcinoma: In contrast, overexpression of circC3P1 decreased cellular migration, proliferation and invasion in human HCC Hep3B and MHCC97-L via a mechanism that involves sponging of miR-4641 and increased expression of phosphoenolpyruvate carboxykinase 1 (PCK1) (Zhong et al., 2018).