Calpain-1 mediated gephyrin cleavage can occur within 1 min in hippocampal membranes (Kawasaki et al., 1997), and cleavage products are increased following in vitro ischemia at 30 min and up to 48 h following ischemic events in vivo (Costa et al., 2015). The gene discussed is CAPN1; the disease is ischemia.