Of the top-ten (based on p-value) differentially expressed proteins in each cell type, only three of them have previously been identified to have a potential role for MS, either through a genetic association, i.e. Lck [20], as a biomarker for MS progression and severity, i.e. macrophage migration inhibitory factor (MIF) [31, 32] or in functional studies, where gasdermin-D (GSDMD) is shown to promote inflammatory demyelination both in human cells and in murine models [33]. This evidence concerns the gene LCK and myeloid sarcoma.