Of note, a selection of the top hit proteins in T cells [TAR binding protein (TARDBP), calnexin (CANX) and AP2 associated kinase 1 (AAK1)] have been shown to play important roles for other neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis [34–37], suggesting common disease mechanisms across neurodegenerative disorders and highlighting the importance for these proteins also in immune cells. This evidence concerns the gene TARDBP and early-onset autosomal dominant Alzheimer disease.