For proteins that did not display any difference in abundance in samples from MS cases and healthy controls, i.e. 24 and 36 proteins from CD4+ and CD8+ T cells, respectively, samples (from both MS patients and healthy controls) were pooled by carriers of the risk allele at each SNP as compared to samples from individuals homozygous for the protective allele for each SNP. The gene discussed is CD8A; the disease is myeloid sarcoma.