BCL2 and autoimmune thrombocytopenic purpura: In a study in ITP patients, the major T-cell abnormalities observed were the increase of Th1/Th2 ratio, the over-expression of Fas ligand on Th1 and Th2 cells, the over-expression of Bcl-2 mRNA and the expansion of oligoclonal T cells in ITP patients compared to controls [14].