CD27 and common variable immunodeficiency: In the last report from the European CVID Registry by the European Society for Immunodeficiencies (ESID), AC were found to be correlated with enteropathy, granulomatous disease, splenomegaly and splenectomy, low IgA level, and later age of onset of CVID, while had been already associated with the reduction of IgG class-switched B-cells (CD27+IgM−IgD−) in peripheral blood [83, 84].