APC and cancer: For 5–10% of cancer cases, significant correlations with specific inherited genes have been identified (e.g. BRCA1 and BRCA2 gene mutations in specific breast cancer types; HPC1 and TLRs in prostate cancer; MLH1, MSH2, MSH6, APC, PTEN in colorectal cancer) (Colditz and Wei, 2012; Wu et al., 2016).