Based on our previous observation of the role of miR-181c-5p (miR-181c) in MT-CO1 suppression and consequent reduction in MMP and ATP production in NRF2-knockdown colon cancer cells [30], we speculated that miR-181c is involved in HIF-1α dysregulation in NRF2-silenced breast cancer cells. The gene discussed is NFE2L2; the disease is malignant colon neoplasm.