As an experimental system, we established a NRF2-knockdown MCF7 (shNRF2-MCF7) and MDA-MB-231 (shNRF2-MDA-MB-231) breast cancer cell lines and corresponding control cell lines (sc-MCF-7, sc-MDA-MB-231) [30], and NRF2 knockdown has been confirmed (Supplementary Figs. S1A and 1B). Here, NFE2L2 is linked to breast cancer.