The HIF-1α-inducible expressions of GLUT1, HK2, PDK1, and LDHA were low in NRF2-silenced breast cancer cells and, accordantly, levels of hypoxia-inducible glycolysis metabolites such as G6P, F16P, GAP, and lactate were diminished by NRF2-silencing. This evidence concerns the gene HK2 and breast cancer.