Given this variation in both practice and interpretation, we undertook a 2-phase study: first, to systematically assess the use of LDC, and investigate current practice and perceptions of LDC among health care professionals working in Pediatric Allergy in the United Kingdom; second, to evaluate the diagnostic utility of LDC compared with OFC outcomes in children undergoing diagnostic food challenge for suspected IgE-mediated food allergy. Here, IGHE is linked to food allergy.