In logistic regression multivariate analysis accounting for population structure of virus and host (using principal component analysis), host IFNL4 genotype (CC vs non-CC), cirrhosis status, and previous treatment status, the polymorphism A150V was associated with an increase in relapse (P = .0027; SVR in patients whose virus carries alanine at position 150 = 88% [n = 138/156] and valine at position 150 = 71% [n = 121/170]) (Supplementary Figure 1C). Here, IFNL4 is linked to Cirrhosis.