Indeed, Adenovirus, Enterovirus, and CMV fecal shedding were linked to several immune markers of mucus alteration (FABP2, IgG ASCA, IgA, and MCP1), epithelial disruption (zonulin and EGF), and T cell proliferation, activation, and infiltration (CXCL16, IL10, and CD40L), hence reinforcing their role in the inflammatory response to HIV-1 infection. The gene discussed is CXCL16; the disease is HIV-1 infection.