Overweight and obese participants, including patients with T2DM, had a lower AT pO2 compared to lean controls, which is in line with findings in rodents.25 Furthermore, it has been found that abdominal sWAT pO2 was higher in obese insulin sensitive and obese insulin resistant as compared to lean subjects, with no significant differences between the obese groups.57 Noteworthy, only four lean individuals were included in the latter study. The gene discussed is INS; the disease is type 2 diabetes mellitus.