1,25(OH)2D in prostate epithelium positively correlated with microRNAs 100 and 125b that showed tumor suppressive properties in vitro.27 The same group showed that 1,25(OH)2D can regulate microRNAs and DICER protein in prostatic stroma that positively associates with biochemical recurrence.28 These data suggest that 1,25(OH)2D can have diverse effects on both prostatic epithelial and stromal cells and this cross‐talk may be significant in prostate cancer biology. The gene discussed is DICER1; the disease is Familial prostate cancer.