MAPK8 and autoimmune disease: On the other hand, there are many receptors of proinflammatory cytokines whose gene expression levels were increased in the aged group: some of them are involved in the mediation of immunosuppressive signals, such as Lilrb4, Pilra, Il10ra, and Il1r2; some play pathogenic roles in inflammatory and autoimmune diseases such as rheumatoid arthritis, for example, Il17ra; and Il18rap and Il21r, whose products are involved in the activation of signalling pathways associated with inflammation, including NF-κB, MAPK8, and JAK-STAT.