In univariate analysis, larger tumor size, node-positive disease, negative hormone receptor status (both estrogen and progesterone negative), poor tumor differentiation (G3 tumor, high Ki67), HER2-positive or triple-negative tumor subtype, and no pCR after neoadjuvant chemotherapy were significantly associated with the occurrence of CNS metastases as the first site of metastatic disease. Here, NR4A1 is linked to neoplasm.