Dysfunction of SIPA1L3 has been discussed as a possible contributor to the phenotype of some malignancies as it led to abnormalities of epithelial cell morphogenesis, cytoskeletal structure and adhesion in a colorectal adenocarcinoma cell line and as somatic SIPA1L3 alterations were found in various, mainly epithelial cancer types [18, 19]. The gene discussed is SIPA1L3; the disease is colorectal adenocarcinoma.