TSC1 and acute myeloid leukemia: Analysis of TSC1 and TSC2 revealed the pathogenic variant c.3099C > G, p.(Tyr1033*) [17] in TSC2 (NM_000548.4) in 67.3% (270/401) of the reads in DNA from the renal and in 41.2% (49/119) of reads from the hepatic AML, while it was not detected in any of the 179 reads from blood (Fig. 2a and Additional file 1: Figure S1).