As LRA showed that IGF-1, TT3, FBG, TC, TT4, and hypertension were also associated with thyroid nodules, correction of the above-mentioned factors (i.e., the correction of different confounding factors through Model 1 (unadjusted), Model 2 (adjusted for FBG, TC, TT3, TT4, and hypertension factors), and Model 3 (further adjusted for IGF-1)) was used to further assess the correlation between the 25(OH)D3 level and the incidence of thyroid nodules (Table 5). The gene discussed is IGF1; the disease is thyroid nodule.