Thyroid nodule was analyzed by LRA to reveal the effects of the single factors on the thyroid nodules, including sex, age, 25(OH)D3, IGF-1, FBG, blood lipid, WC, uric acid, thyroid function, liver function, BMI, HbA1c, HOMA-IR, hypertension, smoking history, and drinking history. Here, IGF1 is linked to thyroid nodule.