Vondra et al.’s study demonstrated that the increase in the risk of autoimmune thyroid disease was associated with deficiency of vitamin D. Serum 25(OH)D3 participates in the pathophysiological process of autoimmune thyroid diseases, and the risk of diffuse toxic goiter (Graves’ disease) is associated with the gene encoding vitamin D binding protein and the polymorphism of 1,25(OH) 2D3 specific receptor remove “target cells” [13]. The gene discussed is GC; the disease is toxic diffuse goiter.