TNF and ocular melanoma: We noted significantly higher TNF-α levels in patients with a 3rd degree of OM compared to those with lower intensive RTH-induced reactions (1st and 2nd degree) after 5th (10.40 vs 9.45 ng/ml, p = 0.020) and 7th (10.32 vs 9.60 ng/ml, p = 0.043) week of RTH (supplementary Table 5).