RASGRP3 and medulloblastoma: There is also potential to integrate our current results with new approaches and explore further resolution of disease subclassification (e.g., the proteomic and transcriptomic signatures of these novel subtypes and their constitution at the single-cell level); the first descriptions of the medulloblastoma proteome [1, 10] describe additional heterogeneity within Grp3 and Grp4 and seem to identify subtype II as a distinct Grp3 high-risk subtype.