The inhibition of autoimmune inflammation via TRAIL/TRAIL-R pathway was observed in several genetically deficient animal models.8,10,11,28 In an autoimmune colitis model, TRAIL-R KO mice were also more susceptible to DSS-induced colitis, and we further demonstrated that TRAIL-mediated suppression of gut inflammation was dependent on TRAIL-R. This evidence concerns the gene TNFSF10 and colitis.