As far we know, P14317 (hematopoietic cell-specific Lyn substrate, HCLS1), P63027 (vesicle-associated membrane protein 2, VAMP2), P16402 (histone cluster 1H1 family member d, HIST1H1D) and Q9H0W9 (chromosome 11 open reading frame 54, C11orf54) were not previously related with melanoma or other cancers. The gene discussed is HCLS1; the disease is cancer.