CtBP2, which was enriched in the “bottom” subset is not expressed in CLL but has been shown to participate in PRC2 recruitment at active embryonic stem cells during exit from pluripotency29, which reinforces the view that EZH2/SUZ12 ReMap libraries were biased toward earlier differentiation stages. The gene discussed is CTBP2; the disease is B-cell chronic lymphocytic leukemia.