SLC41A1 and neoplasm: To determine whether the tumour-suppressive effects of SLC41A1 were associated with its function as an Mg2+ transporter, we evaluated the activity of Akt/mTOR in SLC41A1-overexpressing PDAC cells and found that the overexpression of SLC41A1 significantly inhibited Akt/mTOR activity (Figure 5A).