A Cochrane review8 of dietary exclusions for adults and children with eczema published in 2008 did not find any evidence of benefit for exclusion diets in unselected populations (ie, those without clinically suspected food allergies), but did identify one trial which suggested that infants with suspected egg allergy who have positive specific IgE to eggs may benefit from an egg-free diet.9 While this suggests that test-guided dietary management may be worthwhile, both this and two other subsequently published systematic reviews10 11 have called for better-designed and conducted trials. This evidence concerns the gene IGHE and Eczematoid dermatitis.