Thus, the balance between IL-10 and TNF-α seems to be important for immune homeostasis maintenance, as demonstrated by a curative effect of blocking of the IL-10 pathway in several models of bacterial infections such as from Listeria [25], Klebsiella [26], Pseudomonas [23], Streptococcus [27], or Mycobacterium [28]. Here, IL10 is linked to bacterial infectious disease.