EGF and hepatocellular carcinoma: Altogether, it is concluded that S67 and S76 of the three serines involved in the degradation mechanism of PDCD4-protein, are phosphorylated by S6K1 activated via EGF-induced PI3K-Akt-mTOR-S6K1 signaling pathway and S71 and S76 may be phosphorylated independently from the phosphorylation of S67 by TPA mediated signaling pathway in Huh7 hepatoma cells (Figure 7).