They showed that 14-3-3 protein was co-immuno-precipitated with PDCD4-protein when RSK was activated by the PMA treatment of melanoma cells and conclude that 14-3-3 protein interacted with PDCD4 protein phosphorylated at S67, S76, and/or S457 sequestering the PDCD4-protein into the cytoplasm and stimulated the degradation of the protein in the proteasome system [71]. The gene discussed is PDCD4; the disease is melanoma.