Among the various natural products that induce intrinsic apoptosis is the chloroform fraction (CHCl3) of Azorella glabra Wedd., containing polyphenols, flavonoids, terpenoids; induced apoptosis via caspase-3 activation; cleavage of PARP; and repression of Bcl-2 in RPMI8226, SKMM1, MM1S, and MM cell lines [34]. The gene discussed is BCL2; the disease is Miyoshi myopathy.