Interestingly, the authors found that simultaneously pseudoginsenoside F11 inhibited obesity-linked phosphorylation of PPAR-γ at Ser-273 by Cdk5, which in turn disrupted the contact between PPAR-γ and retinoid X receptor RXRα, which eventually disrupted PPAR-γ/RXRα heterodimer formation and its binding to DNA. Here, RXRA is linked to obesity due to melanocortin 4 receptor deficiency.