EDN1 and diabetes mellitus: Studies performed by Wang and al. demonstrated a lowered production of serum NO, ET-1 (endothelin-1), TNF-α and sICAM-1 (soluble intercellular adhesion molecule 1) in rats with streptozotocin-induced diabetes on high fat and high caloric diet treatment with ginseng stem and leaf saponins for 10 weeks (30–60 mg/kg bw) [124].