In hyperglycaemic conditions, overproduction of fibronectin decreases motility of cells and their replication; elevation of VEGF leads to endothelial dysfunction due to the enhancement of capillary formation and cell permeabilization, while the NF-κB activation in turn exaggerates the expression of extracellular proteins, like fibronectin and vasoactive factors (i.e., VEGF). Here, FN1 is linked to endothelial dysfunction.