In another recent example using the 4T1 TNBC mouse model, it was shown that CXCR2+ MDSCs induces cancer cell EMT by IL-6 and these CXCR2+ MDSCs promotes T cell exhaustion, suggesting that CXCR2+ MDSCs may be a potential therapeutic target of TNBC [141]. Here, CXCR2 is linked to cancer.