MTOR and neoplasm: A study by Weyergang, et al. [26] using colon adenocarcinoma cell line and amphiphilic endolysosome-localizing photosensitizer Al(II) phthalocyanine chloride disulfonic acid (AlPcS(2a)) showed that targeting mTOR signaling pathway in PDT caused partial loss of both total and phosphorylated mTOR in both tumor xenografts and cultured cells in vitro and in vivo.