PD-L1 over-expression also constitutes a major obstacle for anti-PD-L1 therapies, since apart from its strong immunosuppressive function over tumor-specific T-cells, PD-L1 also delivers intrinsic signals that enhance cell survival, regulate stress responses and confer resistance toward pro-apoptotic stimuli like interferons (IFNs) [49]. The gene discussed is CD274; the disease is neoplasm.