PDCD1LG2 and melanoma: In accordance to the repressive activity of PD-L1 and PD-L2 over T-cells, genetic amplifications of CD274 and PDCD1LG2 genes have been associated with high local immune cytolytic activity [4] and the enhanced expression of both ligands, with more than 30 different malignancies including lung, melanoma, breast or colon [26,29].