KRAS and lung adenocarcinoma: KRAS involvement in pathways related to both apoptosis inhibition and PD-L1 overexpression turn this oncogene into a potential prognosis marker that should be considered when stratifying patients for immunotherapy, as it has been already reported in patients with lung adenocarcinomas with KRAS mutations [116] and therefore, the rational use of kinase inhibitors targeting PI3K/AKT and MAP kinases in candidate patients for immunotherapy with KRAS mutant tumors should also be considered.