APOE and Alzheimer disease: Potentially, atrophy in AD signature regions and lobar microhemorrhages captured the pathologies more related to AD development,3,15 while the other lesions may have comprised the cerebrovascular contribution to cognitive impairment.40 Previous studies41,42 used demographic information, APOE allele type, and major vascular comorbidities to predict dementia, with similar performance as our base prediction model using similar information.