MSH6 and hereditary neoplastic syndrome: MAC had been reported to more frequently show MSI phenotype.18, 19, 20 Recently, Shen et al12 divided SRCC into two groups according to the percentage of signet ring cells in tumors >50% and <50% and analyzed 13 genes associated with hereditary tumor syndrome, including MLH1, MSH2, MSH6, and PMS2, and found no difference of pathological mutation between two groups.