JAK2 and carcinoma of esophagus: 6, 19, 26 Our previous study indicated that miR‐4286 is significantly increased in NSCLC based on miRNA arrays,6 and similar results were observed in esophageal carcinoma and melanoma.7, 8, 9 A recent study suggested that overexpression of miR‐4286 may promote the development of esophageal carcinoma through JAK2/STAT3 pathway activation by targeting INPP4A. 27 However, the mechanism of miR‐4286 in NSCLC remains unknown.