PTEN and non-small cell lung carcinoma: 4, 28, 29, 30, 31 Furthermore, several studies suggest that miRNA‐mediated downregulation of PTEN might lead to new therapeutic strategies for NSCLC. 32, 33, 34 In this study, using bioinformatics and luciferase assays, we first found that PTEN is a target gene of miR‐4286. Then, we examined the mRNA expression of PTEN in NSCLC tissues and normal lung tissues from 31 NSCLC patients and found that 21 NSCLC tissues (67.74%) had a high miR‐4286 level while presenting low PTEN mRNA expression (Figure 7C).