Among the 250 genes of DNB, 43 genes have been shown in pathogenesis maps of CML, and BCR, TGFBR2, ABL1, CRK, and PIK3R2 may be the key genes leading to the progression of CML, and the remaining genes have also been found in other types of leukemia like AML. The gene discussed is PIK3R2; the disease is acute myeloid leukemia.