It indicates that the up-regulation of SREBF1 promoted the de novo synthesis of fatty acids associated with the upregulation of ACLY, FASN and SCD, increased cholesterol uptake into hepatocytes associated with the upregulation of PCKS9, modulated the fatty acid oxidation in mitochondria associated with the down-regulation of ACACB in most cancers (Fig. 2d, Additional file 4). This evidence concerns the gene ACACB and cancer.