SLC5A1 and diarrheal disease: 1996; Sundaram et al. 1997; Donowitz et al. 2005; Coon et al. 2007). SGLT1 is not only important for Na absorption, but also for glucose absorption which is the most abundant nutrient in the diet (Wright et al. 2006). In fact, the foundation of oral rehydration therapy is preserved SGLT1, which is the cornerstone of therapy for diarrheal diseases in developing countries. SGLT1 is a secondary active transport process requiring a favorable transcellular Na gradient which is provided by the Na+/K+‐ATPase located in the basolateral membrane (BLM) of villus cells (Wright et al. 2007).