IL10 and Arthritis: In addition, humanized anti-Hsp60 mAb (Prozumab) was found to be effective in protecting and suppressing murine models of arthritis and colitis, and the presence of anti-Hsp60 mAb in anti-CD3-stimulated human peripheral blood mononuclear cell (PBMC) cultures downregulated the secretion of pro-inflammatory IL-6 and IFN-ɣ and stimulated anti-inflammatory IL-10 (Ulmansky et al. 2015).