In murine models of arthritis, for instance, active immunization with bacterial or autologous Hsp70—which obviously generated Hsp70-specific immunoglobulins—prevented and arrested the disease symptoms and attenuated inflammation response via induction of IL-10 and Tregs (Wieten et al. 2009; van Herwijnen et al. 2012). Here, IL10 is linked to arthritic joint disease.