It has been establishedthat cognitive and behavioral AD symptoms are correlated with the accumulation ofamyloid plaques in the extracellular environment and with intracellularneurofibrillary tangles, which destroy synapses essential to learning, memory,planning and decision making.4-6 Amyloid plaque formation is due to theaccumulation of Aβ peptide, which, in turn, is caused by a change in the amyloidprecursor protein (APP) cleavage process.7 APPis a transmembrane protein which normally undergoes either neuroprotective oramyloidogenic cleavage. Here, APP is linked to Alzheimer disease.