Onemeta-analysis found an association between levels of C-reactive protein (CRP) - amarker of systemic inflammation (acute phase) - and heightened risk of developingAD.117 Another study noted higherconcentrations of high-sensitivity CRP in AD patients than in healthyindividuals.99 Similarly, high CRP levelsare associated with low memory, visuospatial impairment and low global cognitiveperformance.133,134. This evidence concerns the gene CRP and Alzheimer disease.