MAPT and Alzheimer disease: Changes in brain glucose metabolism contribute to cell degeneration and appear to beassociated with the onset and progression of AD.42 High glucose concentrations, mediated by hypercortisolism, insulinresistance and altered glucose metabolism in the brain, are associated with Aβaccumulation and increased phosphorylation of tau protein.80-85 Various epidemiological studies havedemonstrated an independent association between AD and type 2 diabetes mellitus(DM2).