This suggests a possible oncogenic effect of MAT2B. To test this possibility, liver cancer cell lines were transiently transfected with MAT2B. This induced a ∼2.2-fold and 15-fold increases in MAT2B mRNA expression in HepG2 and Huh7 cells, respectively, without changes of MAT1A and MAT2A mRNA expression (Figure 9A). Here, MAT2B is linked to liver cancer.