MAT1A gene down-regulation at the transcriptional level, in alcoholic hepatitis, cirrhosis and HCC [4], largely depends on MAT1A promoter methylation and histone H4 deacetylation and on MAT1A mRNA interaction with AUF1 protein, which enhances its decay [5–8]. The gene discussed is MAT1A; the disease is hepatocellular carcinoma.