Accordingly, MAT2A up-regulation confers a growth advantage to human HCC and colon cancer [43, 44] as well as leukemic cells [45], and its downregulation by specific siRNA inhibits BrdU incorporation and induces apoptosis in RKO adenocarcinoma and HepG2 hepatoblastoma cells [46]. The gene discussed is MAT2A; the disease is adenocarcinoma.