Specifically, we demonstrated that miR-203 targets the 3’-UTR of MAT2A and MAT2B genes, inhibiting their expression in liver cancer cell lines, and contributes to HCC prognosis, being more expressed in HCCs with better prognosis, and its expression being inversely correlated with HCC proliferation and aggressiveness markers. This evidence concerns the gene MAT2B and hepatocellular carcinoma.