EIF4EBP1 and B-cell chronic lymphocytic leukemia: Our findings support these reports of the effect of PIM kinase inhibitors on the translation machinery of cancer cells; AZD1208-treated CLL cells showed a decrease in phosphorylated 4E-BP1 Thr37/46 but not in p706SK or phospho-4E-BP1 Ser65 (Figure 3D–3E).