Although IL-33 was not correlated with UCP1 or COX7A1, it was directly correlated with PR domain containing 16 (PRDM16) in individuals with normoglycemia (r = 0.5; P = 0.02; n = 20) and T2D (r = 0.38; P = 0.01; n = 43) but not in those with prediabetes. Here, IL33 is linked to type 2 diabetes mellitus.