With regard to PRRs, IL-33 was directly correlated with the C-type lectin receptor CD302 in individuals with normoglycemia (r = 0.54; P = 0.01; n = 21) and T2D (r = 0.41; P = 0.004; n = 47) but not in those with prediabetes. Here, IL33 is linked to type 2 diabetes mellitus.