Although HbA1c was reduced in the T2DM patients with oral drug administration of RSG, metformin, or RSG + metformin following intensive insulin therapy, their fasting blood glucose and postprandial blood glucose remained elevated, suggesting that treatment with only metformin and insulin sensitizer did not efficiently control the blood glucose and that addition of other drugs or insulin are necessary. The gene discussed is INS; the disease is type 2 diabetes mellitus.