INS and type 2 diabetes mellitus: The T2DM patients underwent plasma glucose, glycosylate hemoglobin, insulin C-peptide, islet cell antibodies, glutamic acid decarboxylase antibody, lipid, liver function, inflammatory cytokines, and pre- and post-prandial oxidative stress detection after the 14–21 days of intensive insulin therapy and then after the 48 weeks of different treatments.