This study used RSG and RSG combined with metformin to treat patients with newly diagnosed T2DM for 48 weeks after the termination of intensive insulin therapy to compare their changes in inflammatory factors and oxidative stress to those of T2DM patients who continued to receive insulin therapy, thus evaluating the impact of early insulin sensitizers on the risk factors associated with vascular complications in patients with newly diagnosed T2DM. Here, INS is linked to type 2 diabetes mellitus.