In summary, the thiazolidinedione rosiglitazone was previously shown to increase the risk of myocardial infarction and cardiovascular mortality [50], but following the extensive monitoring by the FDA, no new adverse safety data has been demonstrated [51], early and prolonged application of TZD and metformin after intensive insulin therapy in patients with newly diagnosed T2DM had a specific effect on improving inflammatory status and oxidative stress in these patients. This evidence concerns the gene INS and type 2 diabetes mellitus.