It is also should be noted that the risk of developing CVD or HTN in response to dietary caffeine could be related to the genetic variants of the liver enzyme Cytochrome P450 1A2 (CYP1A2), as the strongest predictors of caffeine metabolism, which may modify the association of dietary caffeine sources and incidence of CVD [50]. The gene discussed is CYP1A2; the disease is hypertensive disorder.