The AMPK inducer 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) is equally potent in blocking glucose consumption by LPS-stimulated GM-DCs as 2-DG (13) and AMPK activation after uptake of dead cells induces autophagy, tolerogenic properties, and reduced anti-tumor immune responses (103). This evidence concerns the gene PRKAA1 and neoplasm.