Goblet cell metaplasia and hyperplasia in airway-induced mucin overproduction, in response to many endogenous signaling factors, such as epidermal growth factor (EGF), leukotrienes (LTs), and Th2 cytokines, are widely observed in patients with chronic asthma and severe asthma [3, 4, 42]. This evidence concerns the gene EGF and asthma.