Taken together, our results suggested that OVA- and IL-4-induced airway inflammation and airway mucus hypersecretion were notably blocked by curcumin very likely through a PPARγ-dependent NF-κB signaling pathway in both lung and BEAS-2B cells, indicating that curcumin may be considered an effective therapy for the potential treatment of asthma in the future. This evidence concerns the gene PPARG and asthma.