Thus, luciferase-positive pancreatic adenocarcinoma cells (Luc+ BxPC-3) were loaded in VITVO repopulating the 3D inner core; after 24 hours, adipose-derived mesenchymal stromal cells (AD-MSCs), genetically modified to secrete soluble TRAIL (MSC-sTRAIL)23, were injected in VITVO at different effector:target ratios (E:T 1:10 and 1:30). The gene discussed is TNFSF10; the disease is pancreatic adenocarcinoma.