In the Profile BM, 6 miRs were down-regulated, targeting 32 KEGG pathways, considering the high number of these pathways, we focused our discussion on the KEGG pathways that may play a specific relevance in SSc, such as “Signalling Pathways Regulating Pluripotency Of Stem Cells”, “MAPK Signalling Pathway”, “HIF-1 Signalling Pathway”, “TGF-Beta Signalling Pathway”, “P53 Signalling Pathway” And “PI3K-Akt Signalling Pathway”. Here, TGFB1 is linked to systemic sclerosis.