Interestingly, we found that ADAM12 may be putatively targeted by several miRs (miR-200b-3p, -642a-5p, 483-3p, 519b-3p, -10b-3p, -629-3p, -432-5p, -668-ep in the BM profile; miR-135b-5p, -204-5p, -155-5p in the A profile), speculating that this miRs may play a role in overexpression of profibrotic gene ADAM12 in SSc-MSCs and driving these cells to a profibrotic fate. This evidence concerns the gene ADAM12 and systemic sclerosis.