PDCD2 and cancer: We also observed that several genes negatively regulated by KRT80 induction play central roles in cancer biology including negative regulators of migration (PCDH10, CADM1), tumor suppressors such as CDKN1A and PDCD2, genes involved in DNA repair (RAD50), chromatin remodelers as SMARCE1 and CHD4 and tumor specific antigens (CD276) suggesting a direct link between cytoskeletal reprogramming and several other oncogenic phenotypes (Fig. 7b).