We have previously shown that the type II keratin TAD7 ranked among the most significantly epigenetically reprogrammed TADs when comparing untreated (MCF7, ERα-positive breast cancer cell lines) non-invasive ET-treated (MCF7 cells resistant to Tamoxifen: MCF7T or Fulvestrant: MCF7F) vs. invasive AI-resistant BC cell lines7 (MCF7 that were long term estrogen deprived: LTED cells, and double resistant LTEDT and LTEDF Fig. 1a, b). This evidence concerns the gene KRT80 and breast cancer.