RP1 was also stronglycorrelated with clinical parameters and poor outcomes in breast cancer patients.ChIP and luciferase reporter assays combined with Co-IP assays indicated that KLF5recruits p300 to the RP1 promoter totranscriptionally upregulate RP1 expression.RP1 significantly accelerated breast cancercell proliferation and invasion in vivo and in vitro. The gene discussed is RP1; the disease is breast carcinoma.