RP1 was also stronglycorrelated with clinical parameters and poor outcomes in breast cancer patients.ChIP and luciferase reporter assays combined with Co-IP assays indicated that KLF5recruits p300 to the RP1 promoter totranscriptionally upregulate RP1 expression.RP1 significantly accelerated breast cancercell proliferation and invasion in vivo and in vitro. Here, EP300 is linked to breast cancer.