MKI67 and neoplasm: Comparison of CCNE1 expression in clinicopathological parameters showed that CCNE1 was significantly associated with Tumor Node Metastasis (TNM) stage and lymphatic invasion (P<0.05); however, other clinicopathological parameters like age, gender, tumor size, differentiation grade and Ki-67 expression had no clear correlation with CCNE1 (P>0.05, Table 1).