BCL2 and gastric cancer: Down-regulation of CCNE1 expression suppressed GC cells proliferation, arrested cell cycle in G1 phase, additionally, it participated in chemoresistance, by which CCNE1 could regulate Cisplatin-induced apoptosis and CCNE1 down-regulation enhance the sensitivity of GC cells to Cisplatin, possibly involved in the regulation of Bcl-2 family.